At iQ Biosciences, we specialize in providing top-tier bioconjugation services to produce Antibody-Drug Conjugates (ADCs). Leveraging state-of-the-art technology and a highly skilled team, we ensure that your ADCs meet the highest standards of quality. Our services are designed to accelerate your research and development, bringing innovative therapies to market faster.
Why iQ Biosciences is Your Only Option
Fast Turnaround Time
In the fast-paced world of drug development, time is of the essence. Our streamlined processes and efficient workflows enable us to offer the fastest turnaround times in the industry. We understand the urgency of your projects and are committed to delivering high-quality results promptly.
Proven Success
Our expertise is backed by a track record of success. We have generated ADCs through bioconjugation that have advanced to become therapeutic candidates. This proven capability underscores our commitment to excellence and our ability to deliver results that meet the highest standards.
Client-Centric Approach
At iQ Biosciences, our clients are at the heart of everything we do. We tailor our services to meet your specific needs, providing personalized solutions that align with your goals and objectives. Our client-centric approach ensures that you receive the support and attention necessary to achieve success.
Comprehensive Discovery Services
We provide extensive discovery stage services for ADC development, including bioconjugate chemistry, linker optimization, ADC plasma stability tests, lysosomal-based payload release assessments, and in vitro bioassays like cytotoxicity and internalization assays. Our comprehensive offerings ensure you have all the data needed for informed decisions at every development stage.
Transparent Communication
We believe in building trust through transparency, in addition to the quality of our work. Throughout the bioconjugation process, we maintain open and honest communication, providing regular and detailed updates. This approach keeps you informed and engaged, ensuring you are fully aware of progress, challenges, and key milestones every step of the way.
Lot-to-Lot Stability
Consistency is crucial in bioconjugation, particularly during ADC scale-up. Our rigorous quality control measures ensure lot-to-lot stability, maintaining high performance across each batch. This reduces variability and provides reliable outcomes in both small-scale and large-scale applications, giving you confidence as you progress through development and production.
Accelerate Your Bioconjugate Journey:
From Target Discovery to Preclinical Excellence
- Strategic Consultation & Discovery Planning
- Client Needs Assessment: Collaborate to understand your therapeutic goals.
- Customized Roadmap: Create a customized plan, from target discovery to preclinical validation, aligned with your objectives.
- Target Identification & Screening
- Target Discovery Support: Assist in selecting and validating bioconjugate or ADC targets with in vitro assessments.
- Hit-to-Lead with High-Throughput Screening (HTS) Approach: Optimize hits and leads with high-throughput screening and structure-activity relationship (SAR) studies.
- Lead Optimization & ADC Design
- Custom Conjugate Design: Tailor ADCs to your targets, ensuring linker stability, payload potency, and therapeutic stability.
- Optimization of Linker-Payload and Conjugate: Refine linker-payload and bioconjugation chemistry using advanced technologies (Site-specific conjugation, Next-Generation linker, and Multifunctional conjugation platforms).
- Proof of Concept (POC) Studies
- Lab-Scale Synthesis: Produce small-scale bioconjugates or ADCs to meet initial criteria.
- Preliminary Analytics: Assess binding affinity, target specificity, and stability.
- In Vitro & In Vivo Validation
- In Vitro Testing: Develop and execute bioassays to evaluate potency, internalization, and bystander killing.
- In Vivo Efficacy & Safety Studies: Assess efficacy, PK/PD, and safety in early-stage models.
- Preclinical Development
- Advanced Bioassays: Develop bioassays to support preclinical studies with focus on potency, efficacy, and immunogenicity assessments.
- Process Development: Optimize conjugation processes for scalability and clinical batch production.
- Regulatory Support & Pre-IND Preparation
- Regulatory Consultation: Ensure compliance with regulatory requirements for IND submission.
- Data Package Preparation: Compile comprehensive data packages for pre-IND meetings, facilitating clinical development.
Our ADC Services
Discovery Bioconjugation Services
Our premier discovery bioconjugation services are designed to accelerate your research and development pipeline. At iQ Biosciences, we bring cutting-edge expertise and innovative solutions to the forefront of bioconjugate chemistry. Our team of seasoned scientists specializes in optimizing bioconjugates such as ADCs, Degrader-antibody conjugates (DACs), Antibody-oligonucleotide conjugates (AOCs), and other therapeutic bioconjugates. From initial concept to proof-of-concept studies, we provide comprehensive support, including custom conjugation strategies, advanced analytical characterization, and tailored optimization processes. Partner with us to unlock the full potential of your bioconjugates and achieve groundbreaking results in your therapeutic endeavors.
ADC Process Development
Our ADC process development services are meticulously designed to optimize and scale your antibody-drug conjugates efficiently. We offer a comprehensive range of process development solutions, including conjugation route optimization and the development of scalable conjugation processes that ensure consistency and reproducibility from lab-scale to manufacturing-scale. We implement effective purification strategies to remove unwanted impurities and develop robust analytical methods for thorough ADC characterization and in-process monitoring. Our team ensures a seamless transition from preclinical to clinical and commercial production stages, focusing on maximizing yield and maintaining product quality. With our expertise, you can be confident that your ADCs will be developed with the highest standards of efficiency and scalability.
Analytical Services
We offer a comprehensive suite of analytical services to support the development and characterization of bioconjugates. Our analytical capabilities include structural characterization, purity analysis, stability testing, and impurity profiling. We ensure the highest quality and efficacy of your bioconjugates through rigorous bioassays, stability studies, and quality control testing. Our state-of-the-art analytical methods provide detailed insights into the performance and stability of your bioconjugates, supporting your development process from discovery to commercialization.
The iQ Experience
Tailored Experiments
Your research is important to us. Our scientists will work through each step of the process with you, including assay design, data analysis, and recommendations for future studies.
Streamlined Process
Simplify your workflow. Bypass the middle-man: at iQ Biosciences, you'll get immediate access to our biospecimen inventory, saving you both valuable time and money.
Expertise
We're experts- so you don't have to be. Augmenting years of experience in immunology and working with immune assays, our scientists stay current with the latest publications and technology.
Exceptional Service
We're here to help. We know the challenges you're facing: whether it be through expedited service or our complimentary consulting services, our team is dedicated to helping you reach your goals.
