ADC Research Reagents
Accelerate your preclinical studies with clinically relevant, ready-to-ship ADCs
High-quality conjugates featuring today’s most successful payloads: DXd, MMAE, DM1, and more
Streamlining Complex ADC Research Workflows
We understand the challenges of ADC development from lengthy conjugation protocols to ensuring reproducible results across experiments. At iQ Biosciences, we’ve eliminated these bottlenecks by providing pre-validated, ready-to-use ADC reagents that mirror the most clinically successful platforms in oncology today.
Whether you’re establishing baseline cytotoxicity assays, validating novel targets, or conducting comparative payload studies, our standardized reagents deliver the consistency and scientific rigor your research demands without months of custom synthesis.
Isotype Control ADCs
Essential Controls for Rigorous Experimental Design
Isotype control ADCs are fundamental to distinguishing true target-mediated effects from non-specific antibody interactions, Fc receptor binding, or payload-related background toxicity. We offer isotype controls on both wild-type and Fc-silent (LALAPG) human IgG1 backbones. On the Fc-silent backbone, the LALAPG mutations eliminate binding to activating Fcγ receptors and C1q, so the antibody does not support ADCC, ADCP, or CDC — providing a cleaner baseline for interpreting payload-driven cytotoxicity, especially in assays involving immune effector cells or complement. To support your experimental needs, we provide isotype control ADCs in the following formats:
| Human IgG1 LALAPG | Human IgG1 Wild Type |
|---|---|
| GGFG-DXd | GGFG-DXd |
| SMCC-DM1 | SMCC-DM1 |
| vc-MMAE | vc-MMAE |
Target-specific ADCs
Our target-specific ADCs are designed for functional studies in tumor models expressing defined tumor-associated antigens, enabling precise evaluation of target-mediated activity. Available in multiple payload formats to match your research needs.
| Anti-c-Met Human IgG1 |
|---|
| GGFG-DXd |
| vc-MMAE |
Need Something More Specific?
We Build Custom ADCs, Too.
If our off-the-shelf ADCs are not the right fit, we can generate custom ADCs using your antibody, tailored to your study requirements, including:
- Conjugation and bioanalytical characterization of client-supplied antibodies
- Targeted DAR optimization
- Alternative linker-payload combinations
- Matched isotype control ADCs
From project design through final conjugate production, we work closely with you to develop ADCs that align with your research objectives.
