High-Throughput Conjugation (HTP) Platform
Screen multiple linker-payload combinations and conjugation conditions in parallel — compressing weeks of sequential experiments into a single study.
Why High-Throughput Matters
In ADC discovery, the difference between a good conjugate and a great one often comes down to linker choice, DAR, and conjugation site. Testing these variables sequentially is slow and expensive. Our HTP platform lets you conjugate and test multiple combinations at once — using your provided antibody and linker-payload candidates — so you identify your lead faster and with more confidence.
Parallel Conjugation
Multiple linker-payload combinations and conjugation chemistries run simultaneously in a single study — using your provided reagents, not weeks apart.
Miniaturized Scale
Microgram-level reactions conserve your precious antibody and payload while still generating meaningful analytical and functional data.
Integrated Analytics
Every HTP conjugate is characterized by DAR and purity — so you’re comparing apples to apples when you evaluate your candidates.
What You Can Screen
Linker-Payload Combinations
Compare cleavable vs. non-cleavable linkers, different spacer lengths, or multiple payload classes against the same antibody in a single experiment. You provide the linker-payload candidates; we run the conjugations in parallel.
Conjugation Chemistry
Head-to-head comparison of stochastic vs. site-specific conjugation, or different site-specific approaches (cysteine, glycan, click) on the same antibody.
DAR Optimization
Vary the drug-to-antibody ratio systematically to identify the DAR that balances potency, stability, and PK — before committing to a larger batch.
Antibody Format Comparison
Screen the same payload across IgG1, BsAb, scFv, or other antibody formats to identify which scaffold delivers the best therapeutic profile.
From HTP Hit to Scaled-Up Lead
Once you’ve identified your lead conjugate from the HTP screen, we can take it directly into Stage 2 characterization and Stage 3 scale-up — all under one roof, with no handoff delays.
