The ABCs of ADCs: An Introduction to Antibody-drug Conjugates

The terms “warhead” and “payload” typically invoke impressions of weapons and destruction. However, in a more constructive and positive light, these terms are now also commonly associated with antibody-drug conjugates (ADCs), a class of biologics used to treat cancer. These warheads and cytotoxic payloads are an integral part of ADCs that drive tumor cell death. Coupled to antibodies, ADCs combine the advantage of both modalities to be a potent class of anti-cancer molecules.In this blog, we will discuss the components that make up ADCs, what they are used for, and the future for this class of biologics. What [...]