ADCC: The Antibody Awakens…the Immune System (Part 2)
What is ADCC and why would you need it? This is Part 2 of our series, “ADCC: The Antibody Awakens…the Immune System”. Miss Part 1? Catch up here. Potential Applications & Implications for ADCC assays As alluded to in Part 1, one of the most important applications for ADCC assays [...]
ADCC: The Antibody Awakens…the Immune System (Part 1)
What is ADCC and why would you need it? What is Antibody-Dependent Cell-Mediated Cytotoxicity? Antibody-dependent cell-mediated cytotoxicity (ADCC) is the lysis of target cells mediated by antibodies that recruit effector cells to the target. This is achieved when the antigen recognition domain of the antibody binds antigen on the target, [...]
The Power of Complements… (Part 2)
What is CDC and why would you need it? This is Part 2 of our series, “The Power of Complements…”. Miss Part 1? Catch up here. Potential applications & implications for CDC assays As alluded to in Part 1, one of the most important applications for CDC assays is to [...]
The Power of Complements… (Part 1)
What is CDC and why would you need it? What is Complement-Dependent Cytotoxicity? Complement-Dependent Cytotoxicity (CDC) is a form of cytotoxicity mediated by the host organism’s complement system. Components of the complement system become activated by three main mechanisms and all pathways lead to the formation of the membrane attack [...]
Cytokine Storms a-brewing… (Part 2)
Cytokine Storms a-brewing… (Part 2) Considerations for CRAs? This is Part 2 of our series, “Cytokine Storms a-brewing…”. Miss Part 1? Catch up here. When are cytokine release assays (CRA) required? In the case of TGN1412, the biologic was an antibody. However, any product- whether a large biological molecule or [...]
Cytokine Storms a-brewing… (Part 1)
Cytokine Storms a-brewing… (Part 1) What is a cytokine storm? A cytokine storm, or cytokine release syndrome (CRS), is a clinical event resulting from the infusion of antibody therapies in patients. The patients experience a massive release of pro-inflammatory cytokines, which leads to debilitating symptoms, severe multi-organ failure, and the [...]
