Göttingen Minipig Peripheral Blood Mononuclear Cells (PBMCs)

Göttingen Minipig Peripheral Blood Mononuclear Cells (PBMCs)

$900.00

  • High-quality Göttingen Minipig PBMCs sourced responsibly from a vetted third party facility
  • High viability (> 80%) after thawing
  • Used for a wide variety of immunological, translational, and toxicity studies
  • All orders come with an iQ Certificate of Analysis
  • Normally ships out same business day

SKU: IQB-MpPB1-XX Categories: , , Tags: , ,

Description

About the Göttingen Minipig

Göttingen Minipigs have been widely used in toxicological testing and pharmacological research for over 40 years with their use growing significantly over the past 10-15 years. The term Göttingen derives its origin from the University of Göttingen where in the 1960s three different breeds namely Minnesota Minipig, Vietnamese Potbelly Pig, and the German Landrace were crossbred to obtain the Göttingen Minipig breed for the pigs’ small size and gentle temper, reproduction (fertility and low body weight), and light skin. They are much smaller than common pigs and therefore require less space to house and feed. In addition, they are easier to handle due to their docile nature and require less compound for in vivo experiments.

In addition, because Göttingen Minipigs were specifically bred for research purposes, well-characterized health records have been carefully maintained and curated. Göttingen Minipigs are becoming increasingly popular for pharmaceutical research because of their small size, availability of comprehensive background data, stable genetic background, similarity to humans, better capability to interpret the model, increased practical experience in handling the animal, and its availability in large uniform groups. Göttingen Minipigs are serving humanity by ensuring the development of medicines to treat arthritis, asthma, cardiovascular diseases, diabetes, eye diseases, gastrointestinal diseases, skin conditions and Parkinson’s disease.

Application Summary for Göttingen Minipig Peripheral Blood Mononuclear Cells (PBMCs)

Göttingen Minipig PBMCs have been used for a wide variety of studies for drug discovery/development, assay validation/development, and immunology-based applications. In vitro immunoassays, such as proliferation, cytotoxicity, and cytokine release in response to compounds are increasingly being performed with Göttingen Minipig PBMCs. These experiments lend insight into the translatability of the compound into humans and offer an alternative to other animal species.

Because of the increased utilization in immunology research, characterization studies of Göttingen Minipig PBMCs are increasing. These studies include immunophenotyping of the various myeloid and lymphocyte subsets by flow cytometry and genomic analysis.

Additionally, Göttingen Minipig PBMCs are commonly used for toxicity studies to determine the tolerability and dosing of compounds in an in vitro manner.

Isolation of PBMCs

Peripheral blood is obtained from responsible facilities that have many years of experience collecting samples.

Once at our lab, PBMCs are isolated by performing density centrifugation with Ficoll, a high molecular weight sucrose solution, to remove red blood cells under sterile conditions. Depending on the species (human or non-human) of blood, either 1.077 or 1.084 g/ml Ficoll is used, resulting in a perfect layer of mononuclear cells that are separated from plasma, platelets, granulocytes, and erythrocytes. Additional quality control measures are taken to isolate and prepare PBMCs that ensure the highest viability for cryopreservation and downstream experimental applications.

Cryopreservation and Storage

Our minipig PBMCs are cryopreserved carefully using iQ Biosciences’ cryopreservation protocol that ensures high viability (> 80%) after thawing.

Cells should be stored at < -120°C once they are received, such as within a liquid nitrogen tank (vapor phase and not submerging the vials in liquid nitrogen).

Additional information

Available Size(s)

Format

Cell Type

Tissue Type

Species

Viability

> 80%

Tailored Experiments

Your research is important to us. Our scientists will work through each step of the process with you, including assay design, data analysis, and recommendations for future studies.

Streamlined Process

Simplify your workflow. Bypass the middle-man: at iQ Biosciences, you'll get immediate access to our biospecimen inventory, saving you both valuable time and money.

Expertise

We're experts- so you don't have to be. Augmenting years of experience in immunology and working with immune assays, our scientists stay current with the latest publications and technology.

Exceptional Service

We're here to help. We know the challenges you're facing: whether it be through expedited service or our complimentary consulting services, our team is dedicated to helping you reach your goals.

For US customers, we ship via FedEx Overnight Shipping. Shipping charges will vary per shipping address (based on ZIP code) and are estimated to be $110.

For international (non-US) customers, we work closely with you and our couriers to ensure all necessary documentation is in place for international shipments to significantly reduce the chance of delays at Customs. For the export of non-human primate samples, this includes preparing CITES permits, as well as any other documentation as required by country. Please submit an inquiry to orders@iqbiosciences.com for your estimated time of delivery and shipping charges.

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