Huacaya Alpaca Peripheral Blood Mononuclear Cells (PBMCs)

Huacaya Alpaca Peripheral Blood Mononuclear Cells (PBMCs)

$675.00$1,100.00

  • High-quality Alpaca PBMCs sourced responsibly from a vetted third party facility
  • High viability (> 80%) after thawing
  • Potential uses include:
    • Production of stable single-domain antibodies (nanobodies) for therapeutic and diagnostic applications
    • Vaccine development
    • Autoimmune research
  • All orders come with an iQ Certificate of Analysis
  • Normally ships out same business day

SKU: IQB-ApPB1-XX Categories: , , Tags: , ,

Description

About the Huacaya Alpaca

Alpacas are a member of the camelid family, which also includes camels, llamas, vicuñas, and guanacos. Primarily domesticated in the high Andes of Peru, Bolivia, Ecuador, and Chile, there are two main breeds of alpacas, Huacaya and Suri. Huacaya alpacas are extensively bred not only for their soft and dense fleece but also for their unique biological characteristics, which make them important for scientific research. They have become increasingly prominent in fields such as immunology and biomedical sciences.

Camelids are known to produce “heavy chain IgG antibodies” (HCAb), structurally distinct from those in humans and most other mammals. Unlike conventional antibodies, which consist of two heavy chains and two light chains, camelid antibodies like those from alpacas lack light chains. From these antibodies, smaller single heavy-chain proteins can be derived, known as VHH or nanobodies. These nanobodies can bind to antigens with high specificity and affinity, and their small size allows them to access epitopes that are typically unreachable by traditional antibodies. This characteristic is highly beneficial for diagnostic and therapeutic applications, including targeted drug delivery systems, cancer therapy, and disease diagnostics.

Application Summary for Huacaya Alpaca Peripheral Blood Mononuclear Cells (PBMCs)

Alpaca PBMCs have a broad range of applications in biomedical and immunology research due to their production of nanobodies. These antibodies exhibit structural homology with human VH3 antibodies, which contributes to their reduced immunogenicity compared to conventional antibodies. Single-domain antibodies have been utilized in developing various clinical therapeutics for conditions such as cancer, infectious diseases, autoimmune disorders, and neurological diseases.

Single-domain antibodies are distinguished by their small size, approximately 15 kDa in molecular weight, and they exhibit high thermal and chemical stability, solubility, and target specificity. These properties make them invaluable as diagnostic reagents in various assays. They are particularly useful in techniques aimed at detecting biomarkers, pathogens, and other relevant targets, including ELISA, immunohistochemistry, and flow cytometry.

Isolation of PBMCs

Peripheral blood is obtained from responsible facilities that have many years of experience collecting samples.

Once blood is received at our lab, PBMCs are isolated by performing density centrifugation with Ficoll, a high molecular weight sucrose solution, to remove red blood cells and other non-PBMCs under sterile conditions. An alpaca specific optimized Ficoll density gradient is used, resulting in a defined layer of mononuclear cells that are separated from plasma, platelets, granulocytes, and erythrocytes. Additional quality control measures are taken to isolate and prepare PBMCs that ensure the highest viability for cryopreservation and downstream experimental applications.

Cryopreservation and Storage

Our alpaca PBMCs are cryopreserved carefully using iQ Biosciences’ cryopreservation protocol that ensures high viability (> 80%) after thawing.

Cells should be stored at < -120°C once they are received, such as within a liquid nitrogen tank (vapor phase and not submerging the vials in liquid nitrogen).

Additional information

Available Size(s)

,

Format

Cell Type

Tissue Type

Species

Viability

> 80%

Tailored Experiments

Your research is important to us. Our scientists will work through each step of the process with you, including assay design, data analysis, and recommendations for future studies.

Streamlined Process

Simplify your workflow. Bypass the middle-man: at iQ Biosciences, you'll get immediate access to our biospecimen inventory, saving you both valuable time and money.

Expertise

We're experts- so you don't have to be. Augmenting years of experience in immunology and working with immune assays, our scientists stay current with the latest publications and technology.

Exceptional Service

We're here to help. We know the challenges you're facing: whether it be through expedited service or our complimentary consulting services, our team is dedicated to helping you reach your goals.

For US customers, we ship via FedEx Overnight Shipping. Shipping charges will vary per shipping address (based on ZIP code) and are estimated to be $140.

For international (non-US) customers, we work closely with you and our couriers to ensure all necessary documentation is in place for international shipments to significantly reduce the chance of delays at Customs. For the export of non-human primate samples, this includes preparing CITES permits, as well as any other documentation as required by country. Please submit an inquiry to orders@iqbiosciences.com for your estimated time of delivery and shipping charges.

Austria Austria Flag

Hölzel Diagnostika Handels GmbH
Tel: +49 221 126 02 66
Email: info@hoelzel.de
Web: https://www.hoelzel-biotech.com/

Canada Canada Flag

Cedarlane
Tel: +1 (289) 288-0001
Toll Free (North America): +1 (800) 268-5058
Fax: +1 (289) 288-0020
Email: sales@cedarlanelabs.com
Web: https://www.cedarlanelabs.com

China China Flag

BIOHUB INTERNATIONAL TRADE CO., LTD.
上海起发实验试剂有限公司
Address: Chuansha Rd #6619, Pudong, Shanghai, Zipcode: 201200 P.R.China
Tel: 0086-021-50724187
Phone: +86-15921799099
Fax: 0086-021-50724961
Email: sale3@78bio.com
Web: www.qfbio.com

European Union European Union Flag

Caltag Medsystems Ltd.
Email: office@caltagmedsystems.co.uk
Web: https://www.caltagmedsystems.co.uk

tebu-bio
Web: https://www.tebu-bio.com
Or Find a local contact

Germany Germany Flag

Hölzel Diagnostika Handels GmbH
Tel: +49 221 126 02 66
Email: info@hoelzel.de
Web: https://www.hoelzel-biotech.com/

Zageno
Web: https://zageno.com/

Ireland Ireland Flag

2B Scientific Ltd
Tel: +44(0) 1869 238033
Fax: +44(0) 1869 238034
Email: sales@2BScientific.com
Web: https://www.2bscientific.com

India India Flag

Cell & Gene BioSolutions Pvt. Ltd.
#478 C, SLV Complex, Raghavendra Swamy Mutt Road
Opp. Turahalli Water Tank, Turahalli, Subramanyapura Post
Uttarahalli Hobli, Bengaluru-560061, Karnataka, India
Phone: +91 97317 14670
Phone: +91 98809 25033
Email: info@cgbios.com
Web: www.cgbios.com

Japan Japan Flag

Cosmo Bio Co., Ltd.
Tel: +81 (03) 5632 9610
Fax: +81 (03) 5632 9619
Email: nsmail@cosmobio.co.jp
Web: https://www.cosmobio.co.jp

Qatar Singapore Flag

Sedeer Medical Services and Trading LLC
Tel: +974 4434 9191
Email: info@sedeer.com
Web: https://sedeer.com/

Singapore Singapore Flag

Omnicell Pte Ltd
Tel: +65 6747 0201
Email: enquiry@omnicell.com.sg
Web: https://omnicell.com.sg/</a

South Korea South Korea Flag

BioClone
Tel: +82-2-2690-0058
Email: bioclone@bioclone.co.kr
Web: http://www.bioclone.co.kr

Switzerland Austria Flag

Hölzel Diagnostika Handels GmbH
Tel: +49 221 126 02 66
Email: info@hoelzel.de
Web: https://www.hoelzel-biotech.com/

Taiwan Taiwan Flag
Hycell International Co. Ltd.
Tel: +886-2-2877-1122
Fax: +886-2-2876-1520
Web: http://www.hycell.com.tw

United Kingdom United Kingdom Flag

2B Scientific Ltd
Tel: +44(0) 1869 238033
Fax: +44(0) 1869 238034
Email: sales@2BScientific.com
Web: https://www.2bscientific.com

Caltag Medsystems Ltd.
Tel: +44 (0)1280 827460
Fax: +44 (0)1280 827466
Email: office@caltagmedsystems.co.uk
Web: https://www.caltagmedsystems.co.uk

tebu-bio
Tel: +44 (0)1733 421880
Fax: +44 (0)1733 421882
Email: uk@tebu-bio.com
Web: https://www.tebu-bio.com

Zageno
Web: https://zageno.com/

United States United States Flag

Fisher Scientific
Tel: 1-800-766-7000
Web: https://www.fishersci.com

Quartzy
Web: https://www.quartzy.com

VWR International
Tel: 1-800-932-5000
Web: https://www.vwr.com

Zageno
Web: https://zageno.com/

Go to Top