Description

About the Cynomolgus Monkey (or Cynomolgus Macaque)

Cynomolgus macaques are the most commonly utilized non-human primates in biomedical research. They are employed in numerous research areas, such as immunology, neuroscience, oncology, diabetes, and pharmacology due to their physiology.

Application Summary for Cynomolgus Monkey Bone Marrow Cells

Cynomolgus monkey bone marrow cells (or cyno bone marrow cells) can be used for a wide variety of safety assessment and functional studies. They are commonly employed in pre-clinical settings to ensure biologics are not eliciting unwanted effects or functions on the different cell populations of the bone marrow. Bone marrow cells are also utilized to test the toxicity of compounds on these cells. Additionally, cynomolgus bone marrow can be used in ex-vivo applications for cell population characterization.

Cynomolgus monkey bone marrow cells can also be used to generate mature monocytes and macrophages from progenitor cells in the marrow. These cells are then typically used in co-culture assays with other immune cells to assess their function.

Isolation of Cynomolgus Monkey Bone Marrow Cells

Bone marrow from cynomolgus monkeys is collected responsibly at third party facilities. These facilities are vetted to ensure they operate according to local regulations and laws. Since the facility is local, the marrow is quickly transported to iQ’s facility for processing.

At our facility, bone marrow is carefully removed from the tissue and mechanically dissociated to obtain a single cell suspension under sterile conditions. The suspension is carefully passed through a filter to remove any aggregates and subsequently depleted of red blood cells. The bone marrow is then frozen based on iQ Biosciences’ quality-controlled cryopreservation protocol to promote recoverability and viability once in the end user’s hands.

Cryopreservation and Storage

Our cyno bone marrow cells are cryopreserved carefully using iQ Biosciences’ cryopreservation protocol that ensures high viability (typically > 70%) after thawing.

Cells should be stored at < -120°C once they are received, such as within a liquid nitrogen tank (vapor phase).