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Blog2018-05-30T01:25:58-08:00

ADCP: The Covert MoA for Therapeutic Antibodies You Need to Know About (Part 2)

In our previous blog, we discussed antibody-dependent cellular phagocytosis (ADCP), a mechanism of action for therapeutic antibodies that is becoming increasingly appreciated. In vitro and in vivo experiments show that ADCP, a process where phagocytic cells ingest and lyse opsonized target cells, can clear lymphoma cells in the [...]

By |January 10th, 2019|Categories: Antibody-Dependent Cellular Phagocytosis, Bioservices, Blog|0 Comments

ADCP: The Covert MoA for Therapeutic Antibodies You Need to Know About (Part 1)

Therapeutic antibodies can work through various mechanisms of action.  They can inhibit ligand-independent dimerization to prevent downstream survival and proliferation signaling pathways or induce apoptosis of target cells.  In addition, therapeutic antibodies can activate the immune system to drive antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) to [...]

By |October 3rd, 2018|Categories: Antibody-Dependent Cellular Phagocytosis, Bioservices, Blog|0 Comments

Revisiting Complement, An Old Friend… (Part 3)

After summarizing how the complement system can have both anti-tumor and pro-tumor effects, we conclude our blog series on Reis et al. by discussing the clinical aspects of complement as a target and biomarker.  As discussed in the previous blogs, the imbalance in activation of complement leads to [...]

Revisiting Complement, An Old Friend… (Part 2)

Complement in promotion of tumorigenesis. The imbalance and dysfunction of complement activity and activation can lead to various mechanisms that promote tumorigenesis. These mechanisms can have affects on the immune cells to provide a more favorable tumor growth environment, including: 1) recruitment of MDSCs, 2) suppression of effector T [...]

Revisiting Complement, An Old Friend… (Part 1)

The complement system of the innate immune system has been widely regarded as an early deterrent to infections and a means to clear pathogens by activating a group of proteins that leads to cell lysis, phagocytosis, and inflammation.  In addition, the power of complement has been implicated as a mechanism [...]

T’ing it Up for Bi-Specific Antibodies…(Part 2)

In our previous blog, we discussed the two-predominant types of T cells, and some in vitro assays these cells are employed in to test the function and specificity of bi-specific antibodies.  In this blog, we discuss the in vivo assays that test the efficacy of these antibodies and tie [...]

By |January 9th, 2018|Categories: Bi-specific Antibody, Blog, T Cells|0 Comments