- High-quality woodchuck PBMCs sourced responsibly from a vetted third party facility
- Used for a wide variety of functional assays in response to viral infections
- All orders come with an iQ Certificate of Analysis
- Normally ships out same business day
Woodchuck Peripheral Blood Mononuclear Cells (PBMCs)
About the Marmota Monax Woodchuck
Woodchucks used for research purposes are mostly caught out in the wild and outbred. Some are already infected with woodchuck herpes virus (WHV), while are others are not. However, some commercial laboratories have established in-house woodchuck colonies.
WHV is an ideal model to study the pathogenesis and therapy of hepatitis B virus (HBV) and hepatitis D virus (HDV), which makes woodchuck the most commonly used animal model for the study of these viruses. Research on HBV using the WHV model focuses on disease and viral pathogenesis, in addition to prevention and treatment of HBV infection.
Similarly, toxicity studies for therapeutics against HBV and HDV are performed with woodchucks. In addition, woodchucks are used in the study of hepatocellular carcinoma, in particular those driven by the hepatitis viruses.
Application Summary for Woodchuck PBMCs
Woodchuck PBMCs can be used for a wide variety of immunology-based applications. In-vitro immunoassays, such as proliferation, cytotoxicity, and cytokine release in response to hepatitis are commonly performed with woodchuck PBMCs. Similarly, characterization of cell surface marker or mRNA transcriptional changes in PBMCs in response to hepatitis-infected target cells are performed using woodchuck PBMCs. Finally, dendritic cells can be generated from these PBMCs to study the role of DCs in response to viral infection.
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