Cryopreserved Samples: To use or not to use…
Cryopreserved Samples: To use or not to use... Why use cryopreserved samples? Many of us envy our colleagues that use cell lines for their experiments because the cells are so readily available and abundant. The cells keep growing with little maintenance and there is no restriction on the number of cells [...]
Consider these Points Before Starting Tissue Cross-Reactivity Studies (PART 2)
PART 2:  What to Consider & How to Prepare for TCR studies Considerations for IHC-based TCR Studies According to FDA guidance in ‘‘Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use’’, frozen tissue is recommended for IHC based TCR studies.  When IHC is used [...]
Consider these Points Before Starting Tissue Cross-Reactivity Studies (PART 1)
PART 1:Â Why Drug Development Values TCR Studies What are Tissue Cross-Reactivity studies? Tissue cross-reactivity (TCR) studies are screening assays used to identify the specific and non-specific binding of test biologics (i.e. antibodies or antibody-like proteins) in various human or non-human tissues. If human tissues are used, the primary goal [...]
