The Power of Complements… (Part 2)
What is CDC and why would you need it? This is Part 2 of our series, “The Power of Complements…”. Miss Part 1? Catch up here. Potential applications & implications for CDC assays As alluded to in Part 1, one of the most important applications for CDC assays is to determine if a potential therapeutic antibody can mediate CDC activity. Originally thought to only prevent downstream signaling of the target receptor by blocking its oligomerization or engagement to ligands, most therapeutic antibodies are now suggested to work through multiple mechanisms, including CDC activity. Thus, many companies screen their therapeutic antibody [...]